cyclic dinucleotide — TargetMol Chemicals

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Search Results for " cyclic dinucleotide "

Compounds

Cat No.	Product Name	Synonyms	Targets
T9137	SN-011	[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING
	SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.		STING
T11596	IACS-8803		Others
	IACS-8803 is a potent cyclic dinucleotide STING agonist that exhibits strong systemic antitumor efficacy.		Others
T73939	IACS-8803 diammonium
	IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1].
T73938	IACS-8803 disodium
	IACS-8803 Disodium, a potent cyclic dinucleotide STING agonist, exhibits strong systemic antitumor efficacy [1].
T39829	BPK-25
	BPK-25 is an active acrylamide compound that enhances the degradation of proteins in the nucleosome remodeling and deacetylation (NuRD) complex through a post-translational mechanism involving covalent protein interactio...
T36985	Cyclic di-UMP (sodium salt)
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or ds...
T74727	CL845-PAB-Ala-Val-C5-MC
	CL845-PAB-Ala-Val-C5-MC, a conjugatable STING ligand, derives from the proprietary cyclic dinucleotide CL845 and is designed for bioconjugation.
T36996	MSA-2 dimer
	MSA-2 dimer, a selective and orally active non-nucleotide STING agonist with a dissociation constant (Kd) of 145 μM, demonstrates prolonged antitumor and immunogenic activity. It non-covalently binds to STING as a dimer,...
T38091	3'3'-cGAMP (sodium salt)
	3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP sh...
T77253	β-Nicotinamide adenine dinucleotide reduced dipotassium
	β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation reactions, and as a precursor of cyclic ADP-ribose. It also ...
T35654	2'2'-cGAMP (sodium salt)
	2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that...
T79313	BI 7446		STING
	BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor ...		STING
T13606L	CGAMP disodium
	cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I inte...